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KMID : 0361020010440090951
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 9 p.951 ~ p.956
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Expression of CD44s, v3 and v6 in Squamous Cell Carcinoma of the Head and Neck
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김상현/Sang Hyun Kim
문준환/노호상/문성욱/신철/장희진*/손형래†/최혜진†/Jun Hwan Moon/Ho Sang No/Seong Wook Moon/Chel Shin/Hee Jin Chang*/Hyoung Rae Son†/Hye Jin Choi†
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Abstract
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Background and Objectives : CD44 is a transmembrane glycoprotein that mediates cell adhesion through binding to extracelluar matrix molecules such as hyaluronan. Multiple isoforms of CD44 are generated by alternative splicing of 10 separate exons
(v1-v10). Some of them have been noted as markers for tumor metastasis and prognosis in several studies. We investigated whether CD44s, v3 and v6 may be a useful markers in the head and neck squamous cell carcinoma. materials and Method :
Paraffin
embedded tissue sections, which was diagnosed as squamous cell carcinoma of the head and neck from 41 patients were stained immunohistochemically with monoclonal Ab of CD44s, v3 and v6. The results were compared with the primary tumor status,
lymph
node
metastasis, histopathologic differentiation and survival. Results : Various levels of immunoreactivities of the CD44s, CD44v3 and CD44v6 were detected dominantly in cancer cell membrane. The positive rate of CD44s, CD44v3 and CD44v6 were 59%,
66%,
71%
respectively. The decreased expression of CD44s and CD44v6 was significantly correlated to lymph node metastasis but was not affected by T-stage, histopathologic differentiation and survival. CD44v3 had no correlation with the T-stage, N-stage,
pathologic differentiation nor survival. Conclusion : The expression of CD44s and CD44v6 in the head and neck squamous cell carcinoma may be a biologic marker for lymph node metastasis.
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KEYWORD
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